diff --git a/EXPERIMENTAL.org b/EXPERIMENTAL.org
index a1de269b1..e7b4fcd44 100644
--- a/EXPERIMENTAL.org
+++ b/EXPERIMENTAL.org
@@ -23,6 +23,10 @@ The portable dumper is a feature that will be available with Emacs 27. This new
 dumper should theoretically work on all the three major OSes: GNU/Linux, macOS
 and Windows.
 
+WARNING: pdumper does not work with Native Compilation, so if you get an error
+like: =emacs: Trying to load incoherent dumped eln file=, make sure you disable
+this.
+
 ** Setup
 To test the portable dumper with Spacemacs, follow these steps:
 
diff --git a/core/core-dumper.el b/core/core-dumper.el
index dafbe086e..06ff690d3 100644
--- a/core/core-dumper.el
+++ b/core/core-dumper.el
@@ -104,17 +104,26 @@ the end of the loading of the dump file."
   (declare (indent defun))
   (if (eq 'dumping spacemacs-dump-mode)
       (let ((funcname2 (intern (format "spacemacs//after-dump-%S" funcname))))
-            `(progn
-               (defun ,funcname2 nil ,@body)
-               (add-to-list 'spacemacs-dump-delayed-functions ',funcname2)))
+        `(progn
+           (defun ,funcname2 nil ,@body)
+           (add-to-list 'spacemacs-dump-delayed-functions ',funcname2)))
     `(progn ,@body)))
 
 (defun spacemacs/emacs-with-pdumper-set-p ()
-  "Return non-nil if a portable dumper capable emacs executable is set."
+  "Return non-nil if a portable dumper capable Emacs executable is set and
+native compilation is not in effect."
   (and dotspacemacs-enable-emacs-pdumper
        (file-exists-p
         (locate-file (or dotspacemacs-emacs-pdumper-executable-file "emacs")
-                     exec-path exec-suffixes 'file-executable-p))))
+                     exec-path exec-suffixes 'file-executable-p))
+       (not (spacemacs/emacs-with-native-compilation-enabled-p))))
+
+(defun spacemacs/emacs-with-native-compilation-enabled-p ()
+  "Return non-nill if native compilation is enabled."
+  (and (featurep 'native-compile)
+       (fboundp 'native-compile-available-p)
+       (native-compile-available-p)
+       (not (eql comp-speed -1))))
 
 (defun spacemacs/dump-modes (modes)
   "Load given MODES in order to be dumped."
diff --git a/core/templates/.spacemacs.template b/core/templates/.spacemacs.template
index 4efa397c8..4e258f50a 100644
--- a/core/templates/.spacemacs.template
+++ b/core/templates/.spacemacs.template
@@ -89,9 +89,13 @@ It should only modify the values of Spacemacs settings."
   ;; This setq-default sexp is an exhaustive list of all the supported
   ;; spacemacs settings.
   (setq-default
-   ;; If non-nil then enable support for the portable dumper. You'll need
-   ;; to compile Emacs 27 from source following the instructions in file
+   ;; If non-nil then enable support for the portable dumper. You'll need to
+   ;; compile Emacs 27 from source following the instructions in file
    ;; EXPERIMENTAL.org at to root of the git repository.
+   ;;
+   ;; WARNING: pdumper does not work with Native Compilation, so it's disabled
+   ;; regardless of the following setting when native compilation is in effect.
+   ;;
    ;; (default nil)
    dotspacemacs-enable-emacs-pdumper nil