diff --git a/Makefile.am b/Makefile.am
index 1a3ca227a4..9803ba5dc7 100644
--- a/Makefile.am
+++ b/Makefile.am
@@ -39,6 +39,7 @@ do_subst = $(SED)					\
   -e 's,[@]GUILE[@],$(GUILE),g'				\
   -e 's,[@]guilemoduledir[@],$(guilemoduledir),g'	\
   -e 's,[@]guileobjectdir[@],$(guileobjectdir),g'	\
+  -e 's,[@]abs_top_builddir[@],$(abs_top_builddir),g'	\
   -e 's,[@]localedir[@],$(localedir),g'
 
 scripts/guix: scripts/guix.in Makefile
diff --git a/scripts/guix.in b/scripts/guix.in
index 0a3ab1f64d..e0194d6ea2 100644
--- a/scripts/guix.in
+++ b/scripts/guix.in
@@ -1,4 +1,4 @@
-#!@GUILE@ \
+#!@abs_top_builddir@/guile \
 --no-auto-compile -e main -s
 !#
 ;;; GNU Guix --- Functional package management for GNU