diff --git a/gnu/packages/bioconductor.scm b/gnu/packages/bioconductor.scm
index 9cdb8f9b06..287b024e5d 100644
--- a/gnu/packages/bioconductor.scm
+++ b/gnu/packages/bioconductor.scm
@@ -4542,13 +4542,13 @@ (define-public r-tximport
 (define-public r-variantannotation
   (package
     (name "r-variantannotation")
-    (version "1.38.0")
+    (version "1.40.0")
     (source (origin
               (method url-fetch)
               (uri (bioconductor-uri "VariantAnnotation" version))
               (sha256
                (base32
-                "0c9r00j8a3bs6n0dv4wi17jc1ljzvr3r2bi4h9axhcsf2ip906rh"))))
+                "1r9kayp0hxcwls08lv2fh0cmf9ks0lqx3k31c1zn4asw4dyqpgva"))))
     (properties
      `((upstream-name . "VariantAnnotation")))
     (propagated-inputs