diff --git a/gnu/packages/audio.scm b/gnu/packages/audio.scm
index 8ec78f665c..70b0f1181c 100644
--- a/gnu/packages/audio.scm
+++ b/gnu/packages/audio.scm
@@ -3210,7 +3210,7 @@ (define-public rubberband
 (define-public rtmidi
   (package
     (name "rtmidi")
-    (version "4.0.0")
+    (version "5.0.0")
     (source (origin
               (method url-fetch)
               (uri (string-append "https://www.music.mcgill.ca/~gary/rtmidi"
@@ -3218,7 +3218,7 @@ (define-public rtmidi
               (file-name (string-append "rtmidi-" version ".tar.gz"))
               (sha256
                (base32
-                "1k962ljpnwyjw9jjiky2372khhri1wqvrj5qsalfpys31xqzw31p"))))
+                "1ff2yfq3k4l209fr71v3w98fpjjv1chs09vkbmxj03lcikahxns8"))))
     (build-system gnu-build-system)
     (inputs
      (list jack-1 alsa-lib))
@@ -3232,6 +3232,19 @@ (define-public rtmidi
 input/output.")
     (license license:expat)))
 
+(define-public rtmidi-4.0
+  (package
+    (inherit rtmidi)
+    (version "4.0.0")
+    (source (origin
+              (method url-fetch)
+              (uri (string-append "https://www.music.mcgill.ca/~gary/rtmidi"
+                                  "/release/rtmidi-" version ".tar.gz"))
+              (file-name (string-append "rtmidi-" version ".tar.gz"))
+              (sha256
+               (base32
+                "1k962ljpnwyjw9jjiky2372khhri1wqvrj5qsalfpys31xqzw31p"))))))
+
 (define-public sratom
   (package
     (name "sratom")
diff --git a/gnu/packages/music.scm b/gnu/packages/music.scm
index 1c34ae621c..08b5ac16e9 100644
--- a/gnu/packages/music.scm
+++ b/gnu/packages/music.scm
@@ -17,7 +17,7 @@
 ;;; Copyright © 2018 nee <nee.git@hidamari.blue>
 ;;; Copyright © 2018, 2021 Stefan Reichör <stefan@xsteve.at>
 ;;; Copyright © 2018 Pierre Neidhardt <mail@ambrevar.xyz>
-;;; Copyright © 2018, 2019, 2021 Ludovic Courtès <ludo@gnu.org>
+;;; Copyright © 2018-2019, 2021-2022 Ludovic Courtès <ludo@gnu.org>
 ;;; Copyright © 2018 Björn Höfling <bjoern.hoefling@bjoernhoefling.de>
 ;;; Copyright © 2019 Gabriel Hondet <gabrielhondet@gmail.com>
 ;;; Copyright © 2019 Timotej Lazar <timotej.lazar@araneo.si>
@@ -3862,7 +3862,7 @@ (define-public milkytracker
      `(("alsa-lib" ,alsa-lib)
        ("lhasa" ,lhasa)
        ("jack" ,jack-1)
-       ("rtmidi" ,rtmidi)
+       ("rtmidi" ,rtmidi-4.0)
        ("sdl" ,sdl2)
        ("zlib" ,zlib)
        ("zziplib" ,zziplib)))
@@ -6141,7 +6141,7 @@ (define-public zrythm
       ("pulseaudio" ,pulseaudio)
       ("reproc" ,reproc)
       ("rubberband" ,rubberband)
-      ("rtmidi" ,rtmidi)
+      ("rtmidi" ,rtmidi-4.0)
       ("sdl2" ,sdl2)
       ("xdg-utils" ,xdg-utils)
       ("zstd" ,zstd "lib")))