diff --git a/gnu/packages/python-science.scm b/gnu/packages/python-science.scm
index 1966d72e09..8df311baea 100644
--- a/gnu/packages/python-science.scm
+++ b/gnu/packages/python-science.scm
@@ -675,26 +675,31 @@ (define-public python-statannot
 (define-public python-upsetplot
   (package
     (name "python-upsetplot")
-    (version "0.4.1")
+    (version "0.6.0")
     (source
      (origin
        (method url-fetch)
        (uri (pypi-uri "UpSetPlot" version))
        (sha256
         (base32
-         "0kwljcmsvrxm33y3ssham2bwv4a5m31mv96y9h18va0cv7s3mqn1"))))
+         "11zrykwnb00w5spx4mnsnm0f9gwrphdczainpmwkyyi50vipaa2l"))
+       (modules '((guix build utils)))
+       (snippet
+        ;; Patch for compatibility with newer setuptools:
+        ;; https://github.com/jnothman/UpSetPlot/pull/178
+        '(substitute* "upsetplot/data.py"
+           (("import distutils")
+            "from distutils.version import LooseVersion")
+           (("if distutils\\.version\\.LooseVersion")
+            "if LooseVersion")))))
     (build-system python-build-system)
     (arguments
-     `(#:phases
+     '(#:phases
        (modify-phases %standard-phases
-         (add-after 'unpack 'fix-versioning
-           (lambda _
-             (substitute* "setup.py"
-               (("pytest-cov<2.6") "pytest-cov"))))
          (replace 'check
-           (lambda* (#:key inputs outputs #:allow-other-keys)
-             (add-installed-pythonpath inputs outputs)
-             (invoke "pytest" "-v" "--doctest-modules"))))))
+           (lambda* (#:key tests? #:allow-other-keys)
+             (when tests?
+               (invoke "pytest" "-v" "--doctest-modules")))))))
     (propagated-inputs
      (list python-matplotlib python-pandas))
     (native-inputs