diff --git a/gnu/packages/cran.scm b/gnu/packages/cran.scm
index 4ad1bfa760..f76f50b68d 100644
--- a/gnu/packages/cran.scm
+++ b/gnu/packages/cran.scm
@@ -9216,6 +9216,14 @@ (define-public r-reticulate
         (base32
          "0b1szzsqyc8wcfpkn5517bb1ds064vs2hky71my3p74kfngay991"))))
     (build-system r-build-system)
+    (arguments
+     (list
+      #:phases
+      '(modify-phases %standard-phases
+         (add-after 'unpack 'build-reproducibly
+           (lambda _
+             (setenv "PYTHONHASHSEED" "0")
+             (setenv "PYTHONDONTWRITEBYTECODE" "1"))))))
     (inputs (list python))
     (propagated-inputs
      (list r-here