diff --git a/gnu/packages/gnome.scm b/gnu/packages/gnome.scm
index a0238f91aa..04e2b2f172 100644
--- a/gnu/packages/gnome.scm
+++ b/gnu/packages/gnome.scm
@@ -5295,6 +5295,13 @@ (define-public gnome-tweak-tool
        #:imported-modules ((guix build python-build-system)
                            ,@%glib-or-gtk-build-system-modules)
        #:phases (modify-phases %standard-phases
+                  (add-after 'install 'wrap-program
+                    (lambda* (#:key outputs #:allow-other-keys)
+                      (let ((out               (assoc-ref outputs "out"))
+                            (gi-typelib-path   (getenv "GI_TYPELIB_PATH")))
+                        (wrap-program (string-append out "/bin/gnome-tweak-tool")
+                          `("GI_TYPELIB_PATH" ":" prefix (,gi-typelib-path))))
+                      #t))
                   (add-after 'install 'wrap
                     (@@ (guix build python-build-system) wrap)))))
     (native-inputs