diff --git a/gnu/packages/bioconductor.scm b/gnu/packages/bioconductor.scm
index 9a0a641402..8059e89c27 100644
--- a/gnu/packages/bioconductor.scm
+++ b/gnu/packages/bioconductor.scm
@@ -20538,13 +20538,13 @@ (define-public r-s4arrays
 (define-public r-s4vectors
   (package
     (name "r-s4vectors")
-    (version "0.40.1")
+    (version "0.40.2")
     (source (origin
               (method url-fetch)
               (uri (bioconductor-uri "S4Vectors" version))
               (sha256
                (base32
-                "0pja00ssl1pd16v3bls3aybml2cwanylx8igf596zha5srcf5l5h"))))
+                "10lryil0psfyal0006rbhj0dbxyn8f7mpp11h758zc217cxsdnac"))))
     (properties
      `((upstream-name . "S4Vectors")))
     (build-system r-build-system)