diff --git a/gnu/local.mk b/gnu/local.mk
index 6e12f9cdb1..295be3c67c 100644
--- a/gnu/local.mk
+++ b/gnu/local.mk
@@ -1719,7 +1719,6 @@ dist_patch_DATA =						\
   %D%/packages/patches/python-3-fix-tests.patch			\
   %D%/packages/patches/python-3-hurd-configure.patch		\
   %D%/packages/patches/python-3-no-static-lib.patch		\
-  %D%/packages/patches/python-apsw-3.39.2.1-test-fix.patch	\
   %D%/packages/patches/python-aionotify-0.2.0-py3.8.patch	\
   %D%/packages/patches/python-argcomplete-1.11.1-fish31.patch	\
   %D%/packages/patches/python-cross-compile.patch		\
diff --git a/gnu/packages/databases.scm b/gnu/packages/databases.scm
index b74762789a..9d1eec5ea0 100644
--- a/gnu/packages/databases.scm
+++ b/gnu/packages/databases.scm
@@ -173,6 +173,7 @@ (define-module (gnu packages databases)
   #:use-module (guix build-system go)
   #:use-module (guix build-system meson)
   #:use-module (guix build-system perl)
+  #:use-module (guix build-system pyproject)
   #:use-module (guix build-system python)
   #:use-module (guix build-system qt)
   #:use-module (guix build-system ruby)
@@ -3590,7 +3591,7 @@ (define-public python-pickleshare
 (define-public python-apsw
   (package
     (name "python-apsw")
-    (version "3.39.2.1")
+    (version "3.40.0.0")
     ;; The compressed release has fetching functionality disabled.
     (source
      (origin
@@ -3600,24 +3601,23 @@ (define-public python-apsw
              version "/apsw-" version ".zip"))
        (sha256
         (base32
-         "06x3qgg71xz8l3kz8gz04wkfp5f6zfrg476a4mm1c5hikqyw6ykj"))
-       ;; Cherry-picked from upstream, remove when bumping to 3.39.3.
-       (patches
-        (search-patches "python-apsw-3.39.2.1-test-fix.patch"))))
-    (build-system python-build-system)
-    (native-inputs (list unzip))
-    (inputs (list sqlite-next))         ;SQLite 3.39 required.
+         "02sgja00azvd08wi2wm105apmhp2644s7aw9b1zdg3dkcwjnsiad"))))
+    (build-system pyproject-build-system)
+    (native-inputs
+     (list python-cython unzip))
+    (inputs (list sqlite-next))         ;SQLite 3.40 required.
     (arguments
-     (list #:phases
-           #~(modify-phases %standard-phases
-               (replace 'build
-                 (lambda _
-                   (invoke "python" "setup.py" "build" "--enable-all-extensions"
-                           "--enable=load_extension")))
-               (add-after 'build 'build-test-helper
-                 (lambda _
-                   (invoke "gcc" "-fPIC" "-shared" "-o" "./testextension.sqlext"
-                           "-I." "-Isqlite3" "src/testextension.c"))))))
+     (list
+      #:phases
+      #~(modify-phases %standard-phases
+          (add-before 'build 'build-extensions
+            (lambda _
+              (invoke "python" "setup.py" "build" "--enable-all-extensions"
+                      "--enable=load_extension")))
+          (add-after 'build 'build-test-helper
+            (lambda _
+              (invoke "gcc" "-fPIC" "-shared" "-o" "./testextension.sqlext"
+                      "-I." "-Isqlite3" "src/testextension.c"))))))
     (home-page "https://github.com/rogerbinns/apsw/")
     (synopsis "Another Python SQLite Wrapper")
     (description
diff --git a/gnu/packages/patches/python-apsw-3.39.2.1-test-fix.patch b/gnu/packages/patches/python-apsw-3.39.2.1-test-fix.patch
deleted file mode 100644
index cc233e3ccd..0000000000
--- a/gnu/packages/patches/python-apsw-3.39.2.1-test-fix.patch
+++ /dev/null
@@ -1,27 +0,0 @@
-From 1111f902075169bd0d96cdd10607ef8499f0fed5 Mon Sep 17 00:00:00 2001
-From: Roger Binns <rogerb@rogerbinns.com>
-Date: Mon, 5 Sep 2022 07:12:25 -0700
-Subject: [PATCH] Deal with mismatched SQLITE_ENABLE_COLUMN_METADATA
-
-Address #363
----
- apsw/tests.py   | 2 +-
- 1 files changed, 1 insertions(+), 1 deletion(-)
-
-diff --git a/apsw/tests.py b/apsw/tests.py
-index b4a94d3..256ead0 100644
---- a/apsw/tests.py
-+++ b/apsw/tests.py
-@@ -772,8 +772,8 @@ class APSW(unittest.TestCase):
-         c.execute("drop table foo; create table foo (%s)" % (", ".join(["[%s] %s" % (n, t) for n, t in cols]), ))
-         c.execute("insert into foo([x a space]) values(1)")
-         c.execute("create temp table two(fred banana); insert into two values(7); create temp view three as select fred as [a space] from two")
--        has_full=any(o=="ENABLE_COLUMN_METADATA" or o.startswith("ENABLE_COLUMN_METADATA=") for o in apsw.compile_options)
-+        has_full=any(o=="ENABLE_COLUMN_METADATA" or o.startswith("ENABLE_COLUMN_METADATA=") for o in apsw.compile_options) if apsw.using_amalgamation else hasattr(c, "description_full")
-         for row in c.execute("select * from foo"):
-             self.assertEqual(cols, c.getdescription())
-             self.assertEqual(has_full, hasattr(c, "description_full"))
-
-base-commit: f628374c5857d940067ef26c9ea4e85a08a94f76
---
-2.37.2