diff --git a/gnu/packages/ebook.scm b/gnu/packages/ebook.scm
index 207bbfcdaf..0875dae190 100644
--- a/gnu/packages/ebook.scm
+++ b/gnu/packages/ebook.scm
@@ -198,7 +198,7 @@ (define-public calibre
        ("python-pychm" ,python-pychm)
        ("python-pycryptodome" ,python-pycryptodome)
        ("python-pygments" ,python-pygments)
-       ("python-pyqt" ,python-pyqt)
+       ("python-pyqt-without-qtwebkit" ,python-pyqt-without-qtwebkit)
        ("python-pyqtwebengine" ,python-pyqtwebengine)
        ("python-regex" ,python-regex)
        ("python-speechd" ,speech-dispatcher)
@@ -238,7 +238,7 @@ (define-public calibre
          (add-before 'build 'configure
           (lambda* (#:key inputs outputs #:allow-other-keys)
             (let ((podofo (assoc-ref inputs "podofo"))
-                  (pyqt (assoc-ref inputs "python-pyqt"))
+                  (pyqt (assoc-ref inputs "python-pyqt-without-qtwebkit"))
                   (python-sip (assoc-ref inputs "python-sip"))
                   (out (assoc-ref outputs "out")))
               (substitute* "setup/build.py"